Jason Karlawish

File 11

Jason Karlawish is a physician and author. His novel Open Wound: The Tragic Obsession of Dr. William Beaumont, based on true events along the early 19th century American frontier, is the story of a physician's increasing obsession with achieving fame and fortune. Karlawish is a Professor of Medicine, Medical Ethics and Health Policy at the University of Pennsylvania in Philadelphia, Pennsylvania.

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Lighting up with Leonard

Sunday, September 21, 2014 - 2:12pm

Two years ago, at a conference in Miami on Alzheimer's disease, after a session about risk factors and biomarker predicton models, a colleague remarked to me how Leonard Cohen has been saying onstage that when he turns 80, he will resume smoking. Following that afternoon's...

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My review of Stanley Prusiner's autobiography is published

Tuesday, September 2, 2014 - 9:38pm

 Near the end of Stanley Prusiner’s memoir of his Nobel Prize-winning research into the cause of such devastating neurological diseases as Creutzfeldt-Jakob Disease (CJD) and Mad Cow Disease, he recounts how, after a talk at the Aspen Institute, his host admonished him for delivering overly sobering remarks on Alzheimer’s disease. “You have to give people some hope,” his host told him. “You need to give them some reason to believe that Alzheimer...

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Catching up on me and AD and related disorders

Friday, August 15, 2014 - 10:34am

I've been too, too busy at the desk and also on the road – all of it trying to make sense of Alzheimers disease, dementia and the aging brain/mind. Some key events included attending the Alzheimer's Association International Congress (AAIC) in Copenhagen, Denmark. The image is...

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Alzheimers disease finds a different voice

Wednesday, June 11, 2014 - 1:29am

AP has a story about Peter Bristol, one of the first subjects of the A4 Study – shorthand for the...

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How to assess decisionmaking capacity... an audio lecture

Wednesday, May 28, 2014 - 8:18pm

In April 2014, I delivered on on-line lecture on the assessment of decisionmaking capacity. The talk was organized by NAPSA, the National Adult Protective Services Association, and you can...

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We all have Alzheimer's....

Sunday, May 25, 2014 - 7:00am

The April issue of Health Affairs, is dedicated to Alzheimer’s disease. It’s a thorough and thoughtful set of articles edited by Darmouth’s Julie Bynum, MD.

AlzForum covered the...

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A blood test for Alzheimer's??? Not so fast....

Thursday, March 13, 2014 - 12:22pm

Nature Medicine published a study reporting how in a cohort of 500 someodd adults -- average age in their 70's -- a blood measure of various lipids predicted the group who, over three yeas of follow up, was likely to develop either mild cognitive impairment or Alzheimers' disease dementia. I spoke with...

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How learning your genetic risk can transform you....

Sunday, February 16, 2014 - 2:12pm

The American Journal of Psychiatry reports two remarkable findings: After cognitively normal older adults learns they have the ε4 allele of the APOE gene that increases risk of developing Alzheimer’s disease dementia, they perform worse...

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My Top 10 Books…

Sunday, December 29, 2013 - 1:00am

Order nonspecific, this is my list. Each one has been a close friend with whom I’ve talked to and listened to and, after in some cases, after years apart, looked up and gotten back in touch with.

Middlesex by Jeffrey Eugenides

Sentimental Education by Gustave Flaubert

Lolita by Vladimir Nabakov

Blood Meridian by Cormac McCarthy

The Heart of the Matter by Graeme Greene

Let the Great World Spin by Colum McCann

Prescribing by...

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Been thinking about how we think about agitation in persons with dementia and how, as a result, we treat it, or really fail to treat it....

Friday, November 29, 2013 - 7:34pm

.... because we think of it as just a brain disease.

Yeats’ “Quarrel in Old Age” explains what I’m thinking. First stanza: imagine the speaker; a daughter, just off the phone following a call from the nursing home staff who care for her mother, and, in the second stanza, pay close attention to the punctuation.

“Where had her sweetness gone?
What fanatics invent
In this blind bitter town,
Fantasy or incident
Not worth thinking of...

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